(Formerly Banda Oriental and Cisplatine Province)
Special Terms* [Amb.] E.E. and M.P.= Envoy Extraordinary and Minister Plenipotentiary [Charge d'Affaires] a.i.= ad interim Amb. E. & P. = Ambassador Extraordinary and Plenipotentiary
| June 13, 1900 | LEGATION OPENED |
| June 13, 1900 | Dr. Juan Cuestas, Minister Resident |
| January 28, 1901 | Dr. Juan Cuestas, E.E. and M.P. |
| November 1902 List | Sr. Dr. Luis Alberto de Herrera, Charge d'Affaires a.i. |
| February 1904 List | Sr. Dr. Eduardo Acevedo Diaz, Appt. E.E. and M.P. |
| February 12, 1904 | E.E. and M.P. |
| December 1906 List | Dr. Luis Melian Lafinur, Appt. E.E. and M.P. |
| January 5, 1907 | E.E. and M.P. |
| May 31, 1911 | Dr. Carlos Maria de Pena, E.E. and M.P. |
| (DIED - April 30, 1918) | |
| April 30, 1918 | Hugo V. de Pena, Charge d'Affaires a.i. |
| November 21, 1918 | Sr. Don Pedro Cosio, E.E. and M.P. |
| October 4, 1919 | Dr. Jacobo Varela, Appt. E.E. and M.P. |
| May 12, 1920 | E.E. and M.P. |
| March 29, 1934 | J. Richling, Appt. E.E. and M.P. |
| April 25, 1934 | E.E. and M.P. |
| September 3, 1941 | LEGATION RAISED TO EMBASSY |
| August 25, 1941 | Dr. Juan Carlos Blanco, Appt. Amb. E. and P. |
| September 3, 1941 |
Amb. E. and P. (DEAN - June 1, 1948) (Ambassador removed from Nov. 1948 List) |
| May 3, 1948 | Dr. Jose A. Mora, Charge d'Affaires a.i. |
| November 30, 1948 | Dr. Alberto Dominguez-Campora, Appt. Amb. E&P |
| December 15, 1948 | Amb. E. and P. |
| December 26, 1950 | Dr. Jose A. Mora, Charge d'Affaires a.i. |
| December 15, 1948 | Dr. Jose A. Mora, Appt. Amb. E. and P. |
| December 26, 1950 | Amb. E. and P. |
| September 24, 1956 | Sr. Don Julio A. Lacarte Muro, Appt. Amb. E&P |
| September 28, 1956 | Amb. E. and P. |
| January 29, 1960 | Carlos A. Clulow, Appt. Amb. E. and P. |
| February 16, 1960 | Amb. E. and P. |
| September 23, 1963 | Juan Felipe Yriart, Appt. Amb. E. and P. |
| November 12, 1963 | Amb. E. and P. |
| January 31, 1969 | Dr. Hector Luisi, Appt. Amb. E. and P. |
| January 31, 1969 | Amb. E. and P. |
| November 26, 1974 | Brig. Gen. Jose Perez Caldas, Appt. Amb. E&P |
| November 29, 1974 | Amb. E. and P. |
| May 15, 1980 | H.E. Jorge Pachecq Areco, Appt. Amb. E. and P. |
| June 6, 1980 | Amb. E. and P. |
| July 30, 1982 | Alejandro Vegh Villegas, Appt. Amb. E. and P. |
| September 8, 1982 | Amb. E. and P. |
| December 9, 1983 | Italo L. Sordo Alonso, Minister, Charge d'Affaires ad interim |
| March 2, 1984 | Walter Ravenna, Apptd. Amb. E. and P. |
| March 13, 1984 | Amb. E. and P. |
| September 5, 1985 | Hector Luisi, Appt. |
| September 17, 1985 | Amb. E. and P. |
| September 27, 1990 | Eduardo MacGillycuddy, Appt |
| October 24, 1990 | Amb. E. and P. |
| July 5, 1995 | Alvaro Diez de Medina, Appt |
| September 15, 1995 | Amb. E. and P. |
| May 9, 2000 | Hugo Tomas Fernandez-Faingold, Appt. |
| June 14, 2000 | Amb. E. and P. |
| June 30, 2005 | Carlos Alberto Gianelli Derois , Appt. |
| July 11, 2005 | Amb. E. and P. |
| September 11, 2012 | Juan Carlos Pita Alvariza, Appt. |
| September 19, 2012 | Amb. E. and P. |
|
Special Terms* [Amb.] E.E. and M.P.= Envoy Extraordinary and Minister Plenipotentiary [Charge d'Affaires] a.i.= ad interim Amb. E. & P. = Ambassador Extraordinary and Plenipotentiary |
