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U.S. Department of State

Diplomacy in Action

Office of Counterproliferation Initiatives (ISN/CPI)


ISN/CPI leads efforts to develop, implement, and improve counterproliferation policies, which are designed to impede the proliferation of weapons of mass destruction (WMD). It works closely with the White House and other agencies, including the Departments of Defense, Treasury, Commerce, Homeland Security, and Justice, and with the Intelligence Community, to develop and implement appropriate diplomatic, defense, law enforcement, and rapid response options, and other international measures designed to combat the proliferation of WMD.

Key Missions:

Sanctions: ISN/CPI is responsible for implementing nuclear sanctions under U.S. law and Executive Orders 13382 (Blocking Property of Weapons of Mass Destruction Proliferators and Their Supporters) and 13551 (Blocking Property of Certain Persons with Respect to North Korea).

Implementation of Country-Based United Nations Security Council Resolutions (UNSCRs): ISN/CPI works with other countries to ensure compliance with relevant UNSCRs, including UNSCRs 1718/1874 (North Korea); and UNSCRs 1737/1747/1803/1929 (Iran) as well as their successors.

Proliferation Finance: ISN/CPI leads the Department’s efforts on proliferation finance through interactions with foreign governments and foreign financial institutions and contributes to the Financial Action Task Force’s (FATF) policy development on proliferation finance.

Implementing UN Security Council Resolution 1540: ISN/CPI is responsible for sustaining the obligations UN member states have undertaken in accordance with UN Security Council Resolution 1540 to achieve concrete implementation of 1540 standards. Key functions include: 1) working with UNSC 1540 Committee; 2) responding to requests for assistance; 3) working with other UN partners to maintain political attention and; 4) supporting activities of multilateral bodies or organizations involved in work facilitating the implementation of UNSCR 1540.

Interdiction: ISN/CPI leads the USG effort to identify and stop specific shipments of WMD-related items of concern worldwide, including by chairing the nuclear interdiction working group (NIAG), and works to strengthen global legal authorities to combat WMD trafficking, including by the development and enforcement of nonproliferation-related UN Security Council Resolutions.

PSI: ISN/CPI leads Department involvement in the Proliferation Security Initiative (PSI), through which over 100 nations have pledged to take action to stop shipments of WMD, their delivery systems, and related items. Its responsibilities include leading and/or coordinating PSI activities, bringing additional nations into the Initiative, and negotiating bilateral PSI ship-boarding agreements.

Counterproliferation Strategies designed to identify, track, and shut down procurement networks: ISN/CPI is responsible for developing and implementing tailored counterproliferation strategies, including on an actor-specific, network-specific, and a country-specific basis. It also develops strategies to deal with specific counterproliferation challenges as needed, such as illicit transshipment.

Follow this link for more information on Counterproliferation Initiatives:


Director: Tony Foley

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