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PEPFAR-supported smiling group of women in Mozambique [Sarah Day Smith/PEPFAR US Embassy Maputo]

About Us – PEPFAR

Who We Are

The U.S. President’s Emergency Plan for AIDS Relief (PEPFAR) [1 MB] is the largest commitment by any nation to address a single disease in history, enabled by strong bipartisan support across ten U.S. congresses and four presidential administrations, and through the American people’s generosity. PEPFAR shows the power of what is possible through compassionate, cost-effective, accountable, and transparent American foreign assistance. 

PEPFAR is managed and overseen by the U.S. Department of State’s Office of the U.S. Global AIDS Coordinator and Health Diplomacy. PEPFAR leverages the power of a whole-of-government approach to controlling the global HIV/AIDS epidemic, implemented by seven other U.S. government departments and agencies: the U.S Agency for International Development; the U.S. Department of Health and Human Services and its agencies, including the Centers for Disease Control and Prevention, Health Resources and Service Administration and the National Institutes of Health; the U.S. Department of Defense; the Peace Corps; the U.S. Department of Labor; the U.S. Department of Commerce; and the U.S. Department of the Treasury.

For information on PEPFAR’s senior leadership team, please visit the bio page.

What We Do

Since its inception in 2003, PEPFAR has invested over $100 billion in the global HIV/AIDS response, saving 25 million lives, preventing millions of HIV infections, and supporting several countries to achieve HIV epidemic control – all while significantly strengthening global health security.

PEPFAR’s strategic rigor has allowed the program to significantly expand its lifesaving results [918 KB] and impact without increased financial resources over the past nine years.

PEPFAR funding graph

PEPFAR’s investments also have strengthened the systems that drive effective, efficient, and sustainable health care. These investments create a lasting health system for partner countries to confront other current and future health challenges and enhance global health security.

PEPFAR’s transformative, lifesaving impact is unassailable, but our mission is not yet finished. The HIV pandemic continues to evolve in every community and country, and PEPFAR constantly adapts to address new risk groups, new health challenges, and persistent gaps.

U.S. Department of State

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