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These reports are prepared by the Office of the United States Global AIDS Coordinator in collaboration with the United States Departments of State (including the United States Agency for International Development), Defense, Commerce, Labor, Health and Human Services (including the Centers for Disease Control and Prevention, the Food and Drug Administration, the Health Resources and Services Administration, the National Institutes of Health, and the Office of Global Health Affairs), and the Peace Corps.

Seventeenth Annual Report to Congress (2021)

When the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR) was announced in 2003, an HIV diagnosis was a death sentence for many people around the world. Nearly two decades later, we have the opportunity to do something historic: control and ultimately end the HIV/AIDS epidemic as a public health threat.

At PEPFAR’s inception, this prospect seemed unimaginable. But over the ensuing years, with American leadership and generosity, the U.S. government has saved more than 20 million lives and prevented millions of HIV infections through PEPFAR, moving the HIV/AIDS epidemic from crisis toward control in more than 50 countries. Together with thousands of our partners around the globe, we have helped replace death and despair with vibrant life and hope. According to the Joint United Nations Programme on HIV/AIDS, AIDS-related deaths have been reduced by 60 percent and new HIV infections by 40 percent since their respective peaks in 2004 and 1998. Substantial declines have occurred in the past decade, during which AIDS-related deaths and new infections have decreased by 23 percent and 39 percent, respectively, largely driven by significant progress in eastern and southern Africa.

With strong and sustained bipartisan support across four U.S. presidencies and 10 U.S. congresses, the U.S. government has invested more than $85 billion in the global HIV/AIDS response through PEPFAR and as the largest donor to the Global Fund to Fight AIDS, Tuberculosis and Malaria. This commitment represents the largest in history made by any nation to address a single disease.

2021 Annual Report to Congress [13 MB] (PDF)

Reports of Previous Years

U.S. Department of State

The Lessons of 1989: Freedom and Our Future