Promoting global health security is a core tenet of the U.S. biodefense strategy because infectious disease threats, whether naturally occurring, deliberate, or accidental, have the potential to spread globally and affect American people and interests. The Department of State works and coordinates with partner countries, U.S. government agencies (including the Department of Defense, Department of Health and Human Services, Centers for Disease Control, and National Institutes of Health), and international organizations like the Pan American Health Organization to minimize the risk of infectious diseases to U.S. citizens domestically and abroad, including tourists, students, business travelers, and armed services and diplomatic personnel.