Office Home Office Home About Us Key Topics HomeBureaus & Offices > Bureau of International Security and Nonproliferation ...Office of Cooperative Threat Reduction hide Office of Cooperative Threat Reduction Our Mission ISN’s Office of Cooperative Threat Reduction (CTR), which manages the Global Threat Reduction program, utilizes foreign assistance to prevent proliferator states and terrorist groups from developing or acquiring Weapons of Mass Destruction and delivery systems that could threaten the U.S. homeland and U.S. interests abroad. These efforts include disrupting the funding, transport, and acquisition of WMD material, technology, and expertise by proliferator states such as the People’s Republic of China, DPRK, Iran, Russia, and Syria, as well as preventing WMD attacks by ISIS and other terrorist actors. Funded by the nonproliferation, anti-terrorism, demining and related programs account, CTR programmatic lines of effort include the Biosecurity Engagement Program, Chemical Security Program, Counterproliferation Program, FIRST, Partnership for Nuclear Threat Reduction, and other special projects.