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A Smiling Women Supported By PEPFAR In Mozambique


25 Million Lives Saved

When the U.S. President’s Emergency Plan for AIDS Relief (PEPFAR) was launched in 2003, an HIV diagnosis was a death sentence in much of the world; entire families and communities were falling ill. Over the past 20 years, death and despair have been overwhelmingly replaced with vibrant lives and hope.

With the American people’s generosity, the United States has saved 25 million lives and prevented millions of HIV infections through PEPFAR. Working together with our partners in more than 50 countries, we have accelerated progress toward controlling the HIV/AIDS pandemic – community by community.

A Legacy of Strong Bipartisan Support

PEPFAR has maintained strong bipartisan support across U.S. presidencies and U.S. congresses. In December 2018, the PEPFAR Extension Act of 2018 was signed into law to extend provisions of the United States Leadership Against HIV/AIDS, Tuberculosis, and Malaria Act of 2003 for an additional five years through 2023. PEPFAR’s lifesaving work is enabled through the U.S. government’s unwavering commitment to the program and the American people’s compassion and generosity, as PEPFAR ensures every U.S. taxpayer dollar is optimally focused for impact.

Results and Impact

Over the past 20 years, PEPFAR has had remarkable lifesaving results. As of September 30, 2022, PEPFAR supported life-saving antiretroviral treatment (ART) for nearly 20.1 million people, helping secure the health and welfare of families PEPFAR has enabled 5.5 million babies to be born HIV-free to mothers living with HIV. The program has provided critical care and support for 7 million orphans, vulnerable children, and their caregivers so they can survive and thrive

PEPFAR graphic


PEPFAR has helped prevent HIV infection in men and boys, including by supporting 30 million voluntary medical male circumcisions in east and Southern Africa. Since 2015, new HIV diagnoses among adolescent girls and young women have declined in all geographic areas implementing the PEPFAR-led DREAMS (Determined, Resilient, Empowered, AIDS-free, Mentored, and Safe) public-private partnership.

PEPFAR’s investments also strengthen the systems that drive effective, efficient, and sustainable health care. PEPFAR has helped train 340,000 health care workers to deliver and improve HIV care and other health services, creating a lasting health system for partner countries to confront other current and future health challenges.

PEPFAR’s data dashboard: Panorama Spotlight 

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