The U.S. government estimates the total population at 16.58 million (July 2018 estimate).  According to a 2016 survey by ProDatos, approximately 45 percent of the population is Catholic and 42 percent Protestant.  Approximately 11 percent of the population professes no religious affiliation.  Groups together constituting less than 3 percent of the population include Buddhists, Hindus, Muslims, Jews, and adherents of the Mayan, Xinca, and Afro-Indigenous Garifuna religions.

Christian groups include the Full Gospel Church, Assemblies of God, Central American Church, Prince of Peace Church, independent evangelical Protestant groups, Baptists, the Church of Jesus Christ, Episcopalians, Jehovah’s Witnesses, Lutherans, Presbyterians, Russian Orthodox, and Seventh-day Adventists.

Catholics and Protestants are present throughout the country, with adherents among all major ethnic groups.  According to leaders of Mayan spiritual organizations, as well as Catholic and Protestant clergy, many indigenous Catholics and some indigenous Protestants practice some form of syncretism with indigenous spiritual rituals, mainly in the eastern city of Livingston and in the southern region of the country.

According to Jewish community leadership, approximately 1,000 Jews live in the country.  Muslim leaders stated there are approximately 1,200 Muslims of mostly Palestinian origin, who reside primarily in Guatemala City.  According to local Ahmadi Muslims, there is a small Ahmadi community of approximately 70 members.